James H. Segars, Jr., MD

About

James H. Segars, Jr., MD is Director of the Division of Reproductive Science and Women’s Health Research and Professor of Gynecology and Obstetrics at the Johns Hopkins University School of Medicine. He also leads the Howard W. and Georgeanna Seegar Jones Laboratory of Reproductive Sciences and Women’s Health Research — a laboratory named for the founding figures of modern reproductive endocrinology, reflecting Johns Hopkins’ deep academic tradition in reproductive science.

Dr. Segars earned his undergraduate and medical degrees from Duke University, completed residency and fellowship training at Vanderbilt University Medical Center, and pursued postdoctoral research at the NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

He joined Johns Hopkins in 2015. Previously, he served as Director of the Reproductive Endocrinology and Infertility Research Unit at NIH/NICHD and Professor of Obstetrics and Gynecology at the Uniformed Services University of the Health Sciences.

Clinical Expertise

• Endometriosis (Endometriosis-Related Infertility): Diagnosis and treatment combining laparoscopic evaluation with assisted reproductive technology
• Uterine Fibroids: Assessment and treatment of fibroids affecting fertility, including post-myomectomy fertility strategies
• Reproductive Endocrine Disorders: Systematic management of PCOS, ovarian dysfunction and related conditions
• Recurrent Pregnancy Loss: Etiologic evaluation and individualized treatment for recurrent miscarriage
• Assisted Reproductive Technology (ART): Full-cycle IVF management with individualized protocols for complex cases

Why Choose Dr. Segars

NIH research leadership background: Dr. Segars led the reproductive endocrinology and infertility research unit at NIH/NICHD — one of the world’s foremost reproductive medicine research institutions. He brings research frontiers directly into clinical care, particularly for complex endocrine cases that other centers struggle to diagnose.

Academic influence with 160+ publications: His peer-reviewed work on endometriosis, uterine fibroids and ovarian disorders spans more than 160 publications. He serves on the editorial boards of Reproductive Sciences, Molecular Human Reproduction, Seminars in Reproductive Medicine and Fertility and Sterility.

A laboratory with a historic name: The research laboratory he leads bears the names of Howard W. and Georgeanna Seegar Jones — the pioneering couple of modern reproductive endocrinology. This legacy means patients gain access to Johns Hopkins’ most central reproductive science resources.

ACOG Fellowship: As a Fellow of the American College of Obstetricians and Gynecologists, Dr. Segars adheres to the highest standards of clinical practice.

Professional Affiliations

Dr. Segars is board-certified in Reproductive Endocrinology and Infertility. He is a Fellow of the American College of Obstetricians and Gynecologists, former Director of the REI Research Unit at NIH/NICHD, and currently serves as Director of the Division of Reproductive Science and Women’s Health Research at Johns Hopkins.

Suitable For

Patients with endometriosis-related infertility: A research authority in endometriosis, he provides a complete treatment pathway from medical management through surgical evaluation to IVF.

Patients with uterine fibroids affecting fertility: He specializes in assessing how fibroid location and size affect pregnancy, balancing fibroid management with fertility treatment.

Patients with recurrent pregnancy loss: Leveraging deep expertise in reproductive endocrinology and genetics, he provides systematic evaluation and treatment for repeated miscarriage.

Patients with complex reproductive endocrine disorders: For complex cases such as PCOS and ovarian dysfunction, his research background enables more precise individualized protocols.