Liubin Yang, MD, PhD, FACOG

About

Liubin Yang holds a PhD in molecular and human genetics alongside her medical degree, and she has pointed that combination at one problem: the inherited causes of ovarian failure before 40. Primary ovarian insufficiency means the ovaries stop working before a woman is 40, and in a meaningful share of cases a single gene is doing it. Yang’s laboratory works on gene therapy for that group — repairing the variant rather than managing its consequence — which is a prevention strategy in a specialty that mostly works in rescue. She trained end to end at Baylor College of Medicine, where she took both doctorates and completed her obstetrics and gynecology residency and her REI fellowship in 2023, then returned to Yale, where she finished her biology degree in 2008, as an assistant professor. Her wider agenda is the genetic determinants of ovarian aging and why reserve collapses early in some families and not others.

The embryo-selection side of her work is computational. She developed machine-learning models on time-lapse imaging that separate young from old embryo development patterns (Biology of Reproduction, 2024) and, in F&S Reports in 2022, dynamic algorithms reading embryo morphokinetics to predict clinical pregnancy and live birth — work that sits alongside Emre Seli’s FORTUNE model in the same program. She also published in JAMA Network Open on whether COVID-19 vaccination affects ovarian reserve, a study that answered a question thousands of fertility patients were asking their clinics in 2022, and her earlier genetics work on DNA methylation and hematologic malignancy appeared in Cancer Cell and Nature Reviews Cancer.

Recognition in her field has come from research societies: the American Society of Gene & Cell Therapy career development award in 2022, an NIH K12 women’s health research career development award in 2023, the McKern scholar award in 2024, and the Baylor Robert and Janice McNair MD/PhD fellowship from 2011. She is certified by the American Board of Obstetrics and Gynecology in both obstetrics and gynecology and reproductive endocrinology and infertility, and holds FACOG. Two practical notes before you plan around her: she consults in Mandarin as well as English, and her Yale listing currently shows her not accepting new patients, with no telehealth option and referrals required.

Clinical Expertise

• Primary ovarian insufficiency and premature ovarian failure — evaluation, hormone replacement decisions, and family-building options when reserve is gone
• Genetic causes of diminished ovarian reserve — testing and interpretation for patients whose failure runs in the family
• Time-lapse and morphokinetic embryo assessment, from someone who builds the models rather than buys them
• PGT counselling for patients with a heritable condition in either direction — embryos tested for a known variant
• Fertility preservation and PCOS in a general reproductive endocrinology panel
• Ovarian aging research with clinical translation, including vaccination and environmental exposures affecting reserve

Why Choose Dr. Yang

A geneticist in the room. An MD-PhD in molecular and human genetics on a fertility staff means the inherited causes of ovarian failure get read as genetics, not just as a low AMH.

Gene therapy is her actual research program, funded and awarded by the American Society of Gene & Cell Therapy. Ask her what is clinical, what is preclinical, and what is a promise — she is the person best positioned to draw that line honestly.

She published the study patients asked for. The JAMA Network Open work on COVID vaccination and ovarian reserve addressed a real counselling problem with data rather than reassurance.

Mandarin consultations. The only physician on this panel listed for Mandarin, which for many Connecticut patients changes what an intake history captures.

She is new enough to be current. Fellowship completed in 2023, and her methods — time-lapse imaging read by machine learning — are the ones still being argued about in the field.

Professional Affiliations

American Board of Obstetrics and Gynecology, certified in obstetrics and gynecology and in reproductive endocrinology and infertility; Fellow of the American College of Obstetricians and Gynecologists. American Society of Gene & Cell Therapy, career development award (2022). Society for Reproductive Investigation and the reproductive genetics literature through her ovarian aging and morphokinetics publications. NIH K12 women’s health research career development awardee (2023); McKern scholar (2024); Robert and Janice McNair MD/PhD fellow (from 2011, Baylor College of Medicine). Faculty, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine; clinician at Yale Medicine Fertility Center, Orange campus.

Suitable For

• Women under 40 whose periods and ovarian function failed early, who want the cause pursued rather than only managed
• Families with a pattern of early menopause or ovarian failure, where genetic testing may change what is offered
• Patients wanting a genetic read on repeated IVF failure and on PGT options for a known variant
• Mandarin-speaking patients in the New Haven and Fairfield County area
• Patients who learn the clinic is booking elsewhere — if Yang is not taking new patients, the coordinator can direct you to another physician in the same program rather than to a different center